Using cell-cell interactions to unlock new cancer treatments: Forcing neural crest tumors back onto the developmental path

Evolutionary switch in expression of key markers between mouse and human leads to mis-assignment of cell types in developing adrenal medulla.

Author(s): Kameneva P, V Artemov A, Kastriti, Sundström E, Kharchenko PV, Adameyko I.
Published in: Cancer Cell, 2021, ISSN 1535-6108
Publisher: Cell Press

scFates: a scalable python package for advanced pseudotime and bifurcation analysis from single-cell data (opens in new window)

Author(s): Louis Faure, Ruslan Soldatov, Peter V Kharchenko, Igor Adameyko
Published in: Bioinformatics, 2023, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btac746

Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma (opens in new window)

Author(s): Lourdes Sainero-Alcolado, Muhammad Mushtaq, Judit Liaño-Pons, Aida Rodriguez-Garcia, Ye Yuan, Tong Liu, María Victoria Ruiz-Pérez, Susanne Schlisio, Oscar Bedoya-Reina, Marie Arsenian-Henriksson
Published in: Journal of Experimental & Clinical Cancer Research, Issue 41, 2023, ISSN 1756-9966
Publisher: Nature Publishing House
DOI: 10.1186/s13046-022-02399-x

Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors.

Author(s): Shi Y, Yuan J, Rraklli V, Maxymovitz E, Cipullo M, Liu M, Li S, Westerlund I, Bedoya-Reina, Bullova P, Rorbach J, Juhlin CC, Stenman A, Larsson C, Kogner P, O'Sullivan MJ, Schlisio S, Holmberg J.
Published in: Nucleic Acids Research, 2022, ISSN 1362-4962
Publisher: Oxford Academic

Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma (opens in new window)

Author(s): Cécile Thirant, Agathe Peltier, Simon Durand, Amira Kramdi, Caroline Louis-Brennetot, Cécile Pierre-Eugène, Margot Gautier, Ana Costa, Amandine Grelier, Sakina Zaïdi, Nadège Gruel, Irène Jimenez, Eve Lapouble, Gaëlle Pierron, Déborah Sitbon, Hervé J. Brisse, Arnaud Gauthier, Paul Fréneaux, Sandrine Grossetête, Laura G. Baudrin, Virginie Raynal, Sylvain Baulande, Angela Bellini, Jaydutt
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38239-5

A pan-tissue survey of mosaic chromosomal alterations in 948 individuals (opens in new window)

Author(s): Teng Gao, Maria Eleni Kastriti, Viktor Ljungström, Andreas Heinzel, Arthur S. Tischler, Rainer Oberbauer, Po-Ru Loh, Igor Adameyko, Peter J. Park & Peter V. Kharchenko
Published in: Nature Genetics, 2023, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-023-01537-1

Schwann cell precursors represent a neural crest-like state with biased multipotency (opens in new window)

Author(s): Maria Eleni Kastriti Louis Faure Dorothea Von Ahsen Thibault Gerald Bouderlique Johan Boström Tatiana Solovieva Cameron Jackson Marianne Bronner Dies Meijer Saida Hadjab Francois Lallemend Alek Erickson Marketa Kaucka Viacheslav Dyachuk Thomas Perlmann Laura Lahti Jan Krivanek Jean-Francois Brunet Kaj Fried Igor Adameyko
Published in: EMBO Journal, Issue 02614189, 2022, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021108780

Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?

Author(s): Bedoya-Reina, Schlisio S.
Published in: Cancer Cell, 2021, ISSN 1535-6108
Publisher: Cell Press

Serotonin limits generation of chromaffin cells during adrenal organ development (opens in new window)

Author(s): Polina Kameneva, Victoria I. Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V. Artemov, Tatiana S. Kalinina, Nikita V. Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D. Yakushov, Boris I. Sheftel, Tomas Zikmund,
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30438-w

Theory of branching morphogenesis by local interactions and global guidance

Author(s): Uçar MC, Kamenev D, Sunadome K, Fachet D, Lallemend F, Adameyko, Hadjab S, Hannezo E.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group

The transcriptional portraits of the neural crest at the individual cell level.

Author(s): Erickson AG, Kameneva P, Adameyko
Published in: Seminars in Cell & Developmental Biology, 2022, ISSN 1084-9521
Publisher: Academic Press

Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma (opens in new window)

Author(s): Thale K. Olsen, Jörg Otte, Shenglin Mei, Bethel Tesfai Embaie, Polina Kameneva, Huaitao Cheng, Teng Gao, Vasilios Zachariadis, Ioanna Tsea, Åsa Björklund, Emil Kryukov, Ziyi Hou, Anna Johansson, Erik Sundström, Tommy Martinsson, Susanne Fransson, Jakob Stenman, Shahrzad Shirazi Fard, John Inge Johnsen, Per Kogner, Igor Adameyko, Martin Enge, Peter V. Kharchenko, Ninib Baryawno
Published in: Molecular Cancer, Issue 23, 2024, ISSN 1476-4598
Publisher: BioMed Central
DOI: 10.1186/s12943-024-02091-y

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin.

Author(s): Kameneva P, Artemov AV, Kastriti, Faure L, Olsen TK, Otte J, Erickson A, Semsch B, Andersson ER, Ratz M, Frisén J, Tischler AS, de Krijger RR, Bouderlique T, Akkuratova N, Vorontsova M, Gusev O, Fried K, Sundström E, Mei S, Kogner P, Baryawno N, Kharchenko PV, Adameyko I.
Published in: Nature Genetics, 2021, ISSN 1061-4036
Publisher: Nature Publishing Group

Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges.

Author(s): Kaucka M, Szarowska B, Kavkova M, Kastriti, Kameneva P, Schmidt I, Peskova L, Joven Araus A, Simon A, Kaiser J, Adameyko I.
Published in: Cellular Molecular Life Sciences, 2021, ISSN 1420-682X
Publisher: Birkhauser Verlag

Motor innervation directs the correct development of the mouse sympathetic nervous system (opens in new window)

Author(s): Alek G. Erickson, Alessia Motta, Maria Eleni Kastriti, Steven Edwards, Fanny Coulpier, Emy Théoulle, Aliia Murtazina, Irina Poverennaya, Daniel Wies, Jeremy Ganofsky, Giovanni Canu, Francois Lallemend, Piotr Topilko, Saida Hadjab, Kaj Fried, Christiana Ruhrberg, Quenten Schwarz, Valerie Castellani, Dario Bonanomi, Igor Adameyko
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51290-0

Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes (opens in new window)

Author(s): Teng Gao, Ruslan Soldatov, Hirak Sarkar, Adam Kurkiewicz, Evan Biederstedt, Po-Ru Loh, Peter V Kharchenko
Published in: Nature Biotechnology, Issue 10870156, 2022, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-022-01468-y

Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue (opens in new window)

Author(s): Benjamin Jevans, Fay Cooper, Yuliia Fatieieva, Antigoni Gogolou, Yi-Ning Kang, Restuadi Restuadi, Dale Moulding, Pieter Vanden Berghe, Igor Adameyko, Nikhil Thapar, Peter W Andrews, Paolo De Coppi, Anestis Tsakiridis, Conor J McCann
Published in: Gut, Issue 73, 2024, Page(s) 1441-1453, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-331532

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.

Author(s): Bedoya-Reina OC, Li W, Arceo M, Plescher M, Bullova P, Pui H, Kaucka M, Kharchenko P, Martinsson T, Holmberg J, Adameyko, Deng Q, Larsson C, Juhlin CC, Kogner P, Schlisio S.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group

Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma (opens in new window)

Author(s): Ana Costa, Cécile Thirant, Amira Kramdi, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Orphée Blanchard, Didier Surdez, Nadege Gruel, Eve Lapouble, Gaëlle Pierron, Deborah Sitbon, Hervé Brisse, Arnaud Gauthier, Paul Fréneaux, Mylène Bohec, Virginie Raynal, Sylvain Baulande, Renaud Leclere, Gabriel Champenois, Andre Nicolas, Didier Meseure, Angela Bellini, Aurelien Marabelle, Birgit Geoer
Published in: J Immunother Cancer, Issue 20511426, 2022, ISSN 2051-1426
Publisher: Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2022-004807